Retatrutide is a cutting-edge investigational peptide that functions as a triple agonist of GLP-1, GIP, and glucagon receptors, making it one of the most promising therapies for significant and sustained fat loss. Unlike older GLP-1 agonists like semaglutide, Retatrutide activates additional pathways that not only suppress appetite and improve insulin sensitivity but also increase energy expenditure and fat oxidation. Clinical trials have shown dramatic weight loss results—up to 24% body weight reduction in some participants—along with improvements in blood glucose control, lipid metabolism, and liver fat reduction. Its broad metabolic effects make it a powerful tool for tackling obesity and related metabolic diseases.

Top 4 Peptides to Stack Synergistically with Retatrutide

• CJC-1295 + Ipamorelin – enhances growth hormone and IGF-1 levels, promoting fat metabolism, lean muscle preservation, and recovery.

• AOD-9604 – a fragment of human growth hormone specifically targeting fat breakdown without affecting blood sugar or muscle.

• Tesofensine – a dopamine/noradrenaline/serotonin reuptake inhibitor peptide-like compound that boosts energy, mood, and thermogenesis.

• 5-Amino-1MQ – inhibits NNMT enzyme activity, improving cellular energy expenditure and further enhancing fat loss at the cellular level.