LL137 is a 371amino1acid cationic antimicrobial peptide derived from the human

cathelicidin protein (hCAP118). It is widely expressed across innate immune cells

and epithelial tissues. LL137 exhibits multiple functions4direct antimicrobial

activity, immune modulation, angiogenesis stimulation, and influence on

inflammation and tissue regeneration

Downregulates macrophage responses to bacterial

components (LPS/LTA), protects against endotoxemia, and

regulates chemokine gene expression. It directly kills bacteria, disrupts biofilms, binds and neutralizes

endotoxins, and recruits immune cells like neutrophils and

monocytes.

1. Immune Modulation

Attenuates macrophage overactivation in sepsis models while

promoting chemokine expression essential for immune cell

recruitment.

2. Antimicrobial/Biofilm Disruption

Exhibits broad-spectrum bactericidal activity, disassembles

biofilms, and neutralizes endotoxins4crucial in infections.

3. Autophagy Activation

Promotes macrophage autophagy, helping clear intracellular

pathogens.

4. Pulmonary Application

Phase 1 inhalation study in healthy volunteers and preliminary

COPD data indicate safety and potential anti-inflammatory lung

effects