Mechanism of Action:

• FOXO4 is a transcription factor that interacts with p53, a tumor suppressor protein.

• In senescent cells, FOXO4 binds to p53 and prevents it from triggering apoptosis, allowing damaged cells to linger and cause inflammation.

• FOXO4-DRI disrupts this interaction, releasing p53, which then induces controlled apoptosis in senescent (zombie) cells—but not in healthy cells.

✅ Top Benefits of FOXO4-DRI

🧓 Anti-Aging & Longevity

• Clears senescent cells, which contribute to:
  Wrinkles
  Fatigue
  Organ dysfunction
  Slow tissue healing

• Promotes healthier cell turnover and tissue rejuvenation

🧠 Neuroprotection

• May reduce brain aging and cognitive decline

• Shown in preclinical studies to improve neural plasticity and memory

🦴 Improved Tissue Regeneration

• Supports muscle and bone regeneration in aged models

• Helps restore stem cell activity in aged or damaged tissue

🧬 Anti-Inflammatory Effects

• Removes inflammatory, senescent immune cells

• Lowers systemic markers of chronic inflammation (inflammaging)

💊 Disease Prevention (Experimental)

• May reduce risk factors for:
  Cancer (by clearing senescent cells that may mutate)
  Fibrosis (lung, liver, heart)
  Neurodegeneration
  Metabolic disorders

🧪 Common Stacking Partners

• Epitalon – telomere lengthening

• MOTS-c – mitochondrial rejuvenation

• Thymosin Alpha-1 – immune optimization

• NAD+ boosters – cellular energy restoration